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Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging
https://ouj.repo.nii.ac.jp/records/8165
https://ouj.repo.nii.ac.jp/records/816572559ff8-ba26-429a-be09-c0df49acffcf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Increase in Secretory Sphingomyelinase Activity... (286.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-18 | |||||
| タイトル | ||||||
| タイトル | Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging | |||||
| タイトル | ||||||
| タイトル | Increase in Secretory Sphingomyelinase Activity and Specific Ceramides in the Aorta of Apolipoprotein E Knockout Mice during Aging | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aging | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apolipoprotein_E | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | atherosclerosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ceramide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sphingomyelinase | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | aging | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | apolipoprotein_E | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | atherosclerosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ceramide | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | sphingomyelinase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kobayashi, Keiko
× Kobayashi, Keiko× Nagata, Eri× Sasaki, Kazuki |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 10116 | |||||
| 姓名 | Kobayashi, Keiko | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 10117 | |||||
| 姓名 | Nagata, Eri | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 10118 | |||||
| 姓名 | Sasaki, Kazuki | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 10119 | |||||
| 姓名 | Harada-Shiba, Mariko | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 10120 | |||||
| 姓名 | Kojo, Shosuke | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 10121 | |||||
| 姓名 | Kikuzaki, Hiroe | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Atherosclerosis is caused by many factors, one of which is oxidative stress. We recently demonstrated that systemic oxidative stress increased secretory sphingomyelinase (sSMase) activity and generated ceramides in the plasma of diabetic rats. In addition, we also showed that the total ceramide level in human plasma correlated with the level of oxidized low-density lipoprotein. To investigate the relationship between ceramide species and atherogenesis during aging, we compared age-related changes in ceramide metabolism in apolipoprotein E knock out mice (apoE−/−) and wild type mice (WT). Although the total plasma ceramide level was higher in apoE−/− than that in WT at all ages, it decreased with increasing age. sSMase activity increased at 65 weeks (w) of age in both strains of mice. When apoE−/− developed atherosclerosis at 15 w of age, C18:0, C22:0, and C24:0 ceramide levels in the apoE−/− aorta significantly increased. Furthermore, at 65 w of age C16:0 and C24:1 ceramide levels were significantly higher than those in WT. These results suggested that elevation in levels of specific ceramide species due to sSMase activity contributed to atherogenesis during aging. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Atherosclerosis is caused by many factors, one of which is oxidative stress. We recently demonstrated that systemic oxidative stress increased secretory sphingomyelinase (sSMase) activity and generated ceramides in the plasma of diabetic rats. In addition, we also showed that the total ceramide level in human plasma correlated with the level of oxidized low-density lipoprotein. To investigate the relationship between ceramide species and atherogenesis during aging, we compared age-related changes in ceramide metabolism in apolipoprotein E knock out mice (apoE−/−) and wild type mice (WT). Although the total plasma ceramide level was higher in apoE−/− than that in WT at all ages, it decreased with increasing age. sSMase activity increased at 65 weeks (w) of age in both strains of mice. When apoE−/− developed atherosclerosis at 15 w of age, C18:0, C22:0, and C24:0 ceramide levels in the apoE−/− aorta significantly increased. Furthermore, at 65 w of age C16:0 and C24:1 ceramide levels were significantly higher than those in WT. These results suggested that elevation in levels of specific ceramide species due to sSMase activity contributed to atherogenesis during aging. | |||||
| 書誌情報 |
Biological and Pharmaceutical Bulletin en : Biological and Pharmaceutical Bulletin 巻 36, 号 7, p. 1192-1196, 発行日 2013 |
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| 出版者 | ||||||
| 出版者 | 公益社団法人 日本薬学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10885497 | |||||
